Rev 10/14/2025
Rhabditida
Type species of the genus
Synonyms:
Litomosoides carinii Travassos, 1919
Reported median body size for this species (Length mm; width micrometers; weight micrograms) - Click:
A parasite of the pleural, pericardial and peritoneal cavities of the cotton rat, Sigmodon hispidus, and other rodents in North and South America,
Litomosoides sigmodontis if mice has long been used as a model systems for research on filariasis (Hoffmann et al., 2001)
Definive hosts are rodents.
Ecophysiological Parameters:
Parasitic nematodes enhance their survival by affecting the immune systems of their hosts. Filaria of Litomosoides sigmodontis cause inflammatory responses of mice injected with sublethal doses of lipopolysaccharide (LPS). Female adult worms can mitigate the innate immune response.by causing the mice to develop lower levels of the proinflammatory cytokines in the peripheral blood Hubner et al (2008).
Bain, O., Babayan, S. 2003. Behaviour of filariae: morphological and anatomical signatures of their life style within the arthropod and vertebrate hosts. Filaria Journal 2, 16
Dzimianski, M.T., Marchiaondo, A.A., Cruthers, L.R. 2020. Nematoda, Filarioidea. Chapter 2 in Marchiondo, Cruthers and Fourie (eds) Parasiticide Screening Vol 2. Academic Press.
Durette-Desset, M-C. and Guerrero, R.A. 2006. A new species of Hypocristata (Nematoda, Trichstrongylina, Helimosomoidea) a parasite of Sigmodon hispidus (Cricetidae, Sigmodontinae) from Venezuela. Parasite 2006, 13
Hoffmann, W.H., Pfaff, A.W., Schilx-Key, H., Soboslav, P.T. 2001. Determinants for resistance and susceptibility to microfilaraemia in Litomosoides sigmodontis filariasis. Parasitology 122: 641-649
Hubner MP,Pasche B,.Kalaydjiev S, Soboslay PT,, Lengeling A,, Schulz-Key H,, Mitre E,, Hoffmann WH. 2008. Microfilariae of the Filarial Nematode Litomosoides sigmodontis Exacerbate the Course of Lipopolysaccharide-Induced Sepsis in Mice. Infection and Immunity, 76..